tryptophan hydroxylase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7694	6-fluoro-DL-Tryptophan		5-HT Receptor
	6-fluoro-DL-Tryptophan is an inhibitor of serotonin (5-HT) synthesis.		5-HT Receptor
T21506	Telotristat		Hydroxylase
	Telotristat is the active metabolite of LX1606(Telotristat etiprate), which is an orally bioavailable tryptophan hydroxylase (TPH) inhibitor and shows potential antiserotonergic activity.		Hydroxylase
T15796	LX-1031		Hydroxylase , LPA Receptor
	LX-1031 is an effective inhibitor of tryptophan 5-hydroxylase. LX-1031 decreases serotonin (5-HT) synthesis peripherally.		Hydroxylase , LPA Receptor
T14119	ACT-678689	Compound Example 1.53.4	Hydroxylase
	ACT-678689 (Compound Example 1.53.4) (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].		Hydroxylase
T10142L	P-Ethynylphenylalanine hydrochloride	4-Ethynyl-L-phenylalanine HCL,p-Ethynylphenylalanine hydrochloride(278605-15-5 free base)	Hydroxylase
	p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent and specific inhibitor of TPH[1]. The potential for p-Ethynylphenylalanine hydrochloride to inhibit selectively and reversibly the b...		Hydroxylase
T11897	Telotristat ethyl	LX1606	Hydroxylase
	Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.		Hydroxylase
T6044	Telotristat Etiprate	LX1606 (Hippurate),LX 1606 Hippurate	Hydroxylase
	Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.		Hydroxylase
T1447	Fenclonine	Fenchlonine,PCPA,CP-10188,4-Chloro-DL-phenylalanine,DL-4-Chlorophenylalanine	Hydroxylase
	Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine(CP-10188) acts pharmacologically to dep...		Hydroxylase
T41143	PCPA methyl ester hydrochloride	4-Chloro-DL-phenylalanine methyl ester hydrochloride	5-HT Receptor , Hydroxylase
	pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) is an inhibitor of tryptophan hydroxylase inhibitor and 5-HT synthesis. pCPA methyl ester hydrochloride is permeable across the blood...		5-HT Receptor , Hydroxylase
T15779	LP-533401 hydrochloride		Hydroxylase
	LP-533401 hydrochloride is an inhibitor of tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut.		Hydroxylase
T10142	P-Ethynylphenylalanine	4-Ethynyl-L-phenylalanine	Others , Hydroxylase
	p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine), a tryptophan hydroxylase (TPH) inhibitor, is competitive, effective, selective, and reversible, with a Ki of 32.6 μM.		Others , Hydroxylase
T26258	Telotristat besilate
	Telotristat besilate is an inhibitor of tryptophan hydroxylase.
T16780	Rodatristat	KAR5417	Others
	Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).		Others
T69135	AGN-2979
	AGN-2979 is a tryptophan hydroxylase (TPH) activation inhibitor that shows antidepressant properties in rodent models of depression.
T71888	Fenclonine hydrochloride
	Fenclonine hydrochloride is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin.
T15778	LP-533401		Hydroxylase
	LP-533401 is an inhibitor of Tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut.		Hydroxylase
T16779	Rodatristat ethyl	RVT-014,KAR5585,RVT-1201	5-HT Receptor , Hydroxylase
	Rodatristat ethyl (KAR5585) is a first-of-its-kind orally active and potent tryptophan hydroxylase 1 (TPH1) inhibitor that significantly reduces 5-hydroxytryptamine (5-HT) levels and decreases pulmonary arterial hyperten...		5-HT Receptor , Hydroxylase
T78228	4-Chloro-L-phenylalanine	L-4-Chlorophenylalanine,L-PCPA	5-HT Receptor
	4-Chloro-L-phenylalanine (L-PCPA) is an inhibitor of 5-HT biosynthesis.4-Chloro-L-phenylalanine is also a non-specific antagonist of tryptophan hydroxylase (TPH1 and TPH2).		5-HT Receptor
T79712	TPH1-IN-1
	TPH1-IN-1 (compound 40) is a xanthine derivative that serves as an inhibitor of tryptophan hydroxylase TPH1, with an IC50 of 110.1 nM. Demonstrating robust in vitro activity and liver microsome stability, it effectively ...